The last proposed system of RBC vasodilation inside the existence of nitrite will be the reduction of nitrite to NO by Hb. Brooks initially studied the nitrite Hb interaction in 1937 which do the job was later extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to kind metHb and NO (Brooks, 1937; Doyle